The SRSF5 Polyclonal Antibody (PACO05023) is a valuable tool for researchers studying SRSF5, a member of the serine/arginine-rich splicing factor family involved in RNA processing and alternative splicing. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.SRSF5 plays a crucial role in regulating gene expression through its involvement in alternative splicing, a process that generates multiple protein isoforms from a single gene. Dysregulation of this splicing factor has been implicated in various diseases, including cancer, neurodevelopmental disorders, and autoimmune conditions.
By targeting SRSF5 with this antibody, researchers can investigate its function in different cell types and explore its potential as a therapeutic target in disease settings.This antibody enables precise detection and analysis of SRSF5 protein levels, facilitating studies in molecular biology, cancer biology, and RNA biology. By understanding the role of SRSF5 in gene expression and splicing regulation, researchers can uncover new insights into disease mechanisms and potentially identify novel therapeutic strategies for treating related disorders.
Antibody Name:
SRSF5 Antibody (PACO05023)
Antibody SKU:
PACO05023
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
ELISA:1:20000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human SRp40.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
SFRS5: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Belongs to the splicing factor SR family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Spliceosome; RNA-binding; RNA processingChromosomal Location of Human Ortholog: 14q24Cellular Component: cytoplasm; nuclear speck; nucleolus; nucleoplasm; nucleusMolecular Function: protein bindingBiological Process: mRNA 3'-end processing; mRNA export from nucleus; mRNA processing; mRNA splice site selection; nuclear mRNA splicing, via spliceosome; RNA export from nucleus; termination of RNA polymerase II transcription
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
