The SRPK3 Polyclonal Antibody (PAC042570) is a powerful tool for studying the role of SRPK3, a serine-arginine protein kinase implicated in various cellular processes, including RNA splicing and gene expression regulation. This antibody, produced in rabbits, shows high reactivity with human samples and has been extensively validated for Western blot applications.SRPK3 is known to play a crucial role in the phosphorylation of splicing factors, which in turn influences alternative splicing events that regulate the expression of various genes.
Dysregulation of SRPK3 has been linked to cancer, neurological disorders, and viral infections, making it a promising target for therapeutic intervention.By using the SRPK3 Polyclonal Antibody, researchers can detect and analyze SRPK3 protein levels in different cell types, shedding light on its physiological functions and its potential as a therapeutic target. Studies using this antibody may contribute to the development of novel treatments for diseases associated with aberrant RNA splicing and gene expression.
Antibody Name:
SRPK3 Antibody (PACO42570)
Antibody SKU:
PACO42570
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human SRSF protein kinase 3 protein (1-300AA)
Immunohistochemistry of paraffin-embedded human liver tissue using PACO42570 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO42570 at dilution of 1:100.
Background:
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development.
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
