The SRPK1 Polyclonal Antibody (CAB5854) is a valuable tool for researchers studying SRPK1, a protein kinase involved in the regulation of alternative splicing. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is suitable for use in Western blotting applications. By binding specifically to the SRPK1 protein, this antibody enables the detection and analysis of SRPK1 expression in various cell types, making it an ideal choice for studies in molecular biology and cancer research.
SRPK1 plays a critical role in the control of gene expression through the phosphorylation of serine/arginine-rich proteins, which are essential for pre-mRNA splicing. Dysregulation of SRPK1 has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention. By further understanding the function of SRPK1, researchers can potentially develop novel treatment strategies for cancer and other related conditions.
Product Name:
SRPK1 Polyclonal Antibody
SKU:
CAB5854
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 290-480 of human SRPK1 (NP_003128.3).
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.
Purification Method:
Affinity purification
Gene ID:
6732
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SRPK1 antibody (CAB5854) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
