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SRP68 Antibody (PACO20468)

SKU:
PACO20468
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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SRP68 Antibody (PACO20468)

The SRP68 Antibody (PAC020468) is a polyclonal antibody specifically designed for research involving SRP68, a protein involved in RNA metabolism and protein synthesis. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blotting applications.SRP68 is a key component of the signal recognition particle (SRP), which plays a crucial role in the targeting of proteins to the endoplasmic reticulum during their synthesis. Dysregulation of SRP68 has been implicated in various diseases, including cancer and neurodegenerative disorders.

The SRP68 Antibody enables the detection and analysis of SRP68 in different cell types, making it an essential tool for studies in molecular biology and disease research.Understanding the function and regulation of SRP68 is vital for uncovering its role in cellular processes and disease pathogenesis. The SRP68 Antibody provides researchers with a reliable tool for investigating the mechanisms underlying SRP68-mediated pathways, ultimately contributing to the development of potential therapeutic strategies targeting SRP68-related diseases.

Antibody Name:SRP68 Antibody (PACO20468)
Antibody SKU:PACO20468
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human SRP68
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20468(SRP68 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function.
Synonyms:signal recognition particle 68kDa
UniProt Protein Function:SRP68: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. Belongs to the SRP68 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Endoplasmic reticulum; Nucleolus; RNA-bindingChromosomal Location of Human Ortholog: 17q25.1Cellular Component: focal adhesion; endoplasmic reticulum; cytoplasm; nucleolus; signal recognition particle, endoplasmic reticulum targeting; ribosome; cytosolMolecular Function: signal recognition particle binding; signal sequence binding; endoplasmic reticulum signal peptide binding; 7S RNA bindingBiological Process: response to drug; protein targeting to ER; SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; gene expression
UniProt Protein Details:
NCBI Summary:This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
UniProt Code:Q9UHB9
NCBI GenInfo Identifier:37154869
NCBI Gene ID:6730
NCBI Accession:Q9UHB9.2
UniProt Secondary Accession:Q9UHB9
UniProt Related Accession:Q9UHB9
Molecular Weight:71kDa
NCBI Full Name:Signal recognition particle subunit SRP68
NCBI Synonym Full Names:signal recognition particle 68
NCBI Official Symbol:SRP68  
NCBI Official Synonym Symbols:
NCBI Protein Information:signal recognition particle subunit SRP68
UniProt Protein Name:Signal recognition particle subunit SRP68
UniProt Synonym Protein Names:Signal recognition particle 68 kDa protein
Protein Family:Signal recognition particle
UniProt Gene Name:SRP68  
UniProt Entry Name:SRP68_HUMAN
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