The SRP68 Polyclonal Antibody (PAC012463) is a vital tool for researchers studying SRP68, a key protein involved in RNA metabolism and processing. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SRP68 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and gene expression.SRP68 is essential for the proper functioning of the signal recognition particle (SRP), a ribonucleoprotein complex crucial for targeting proteins to the endoplasmic reticulum. As a core component of SRP, SRP68 plays a critical role in protein synthesis and cellular localization, making it a key player in fundamental biological processes.
Research into SRP68 is vital for understanding cellular mechanisms and can provide valuable insights into diseases related to protein misfolding and trafficking.The use of the SRP68 Polyclonal Antibody (PAC012463) is essential for investigating the role of SRP68 in various cellular processes and diseases, including neurodegenerative disorders, viral infections, and developmental abnormalities. With its reliable performance in Western blot applications, this antibody is a valuable tool for researchers seeking to advance our understanding of RNA biology and its impact on human health.
SRP68: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. Belongs to the SRP68 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Endoplasmic reticulum; Nucleolus; RNA-bindingChromosomal Location of Human Ortholog: 17q25.1Cellular Component: focal adhesion; endoplasmic reticulum; cytoplasm; nucleolus; signal recognition particle, endoplasmic reticulum targeting; ribosome; cytosolMolecular Function: signal recognition particle binding; signal sequence binding; endoplasmic reticulum signal peptide binding; 7S RNA bindingBiological Process: response to drug; protein targeting to ER; SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; gene expression
UniProt Protein Details:
NCBI Summary:
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
