The Anti-SRP54 Antibody (CAB2296) offered by Assay Genie is a polyclonal antibody designed for research involving SRP54, a key protein involved in protein targeting and translocation within the cell. This antibody is raised in rabbits and is highly reactive with human samples, making it a valuable tool for studying the function and localization of SRP54 in various cell types.SRP54, also known as Signal Recognition Particle 54 kDa protein, is essential for the proper targeting of proteins to the endoplasmic reticulum (ER) during the process of protein synthesis. Dysregulation of SRP54 has been implicated in various diseases, including certain types of cancer and neurodegenerative disorders.
Understanding the role of SRP54 in these conditions could lead to potential therapeutic targets for treatment.The Anti-SRP54 Antibody is validated for use in Western blot applications, enabling researchers to detect and analyze the expression of SRP54 in cell lysates. By studying the localization and function of SRP54, researchers can gain insights into its role in cellular processes and disease pathology. This antibody is a valuable tool for those conducting research in the fields of cell biology, molecular biology, and protein targeting mechanisms.
Product Name:
SRP54 Rabbit Monoclonal Antibody
SKU:
CAB2296
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-504 of human SRP54 (P61011).
Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiation and protein targeting to ER. Located in cytosol and nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. Implicated in severe congenital neutropenia 8.
Purification Method:
Affinity purification
Gene ID:
6729
Clone Number:
ARC1904
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SRP54 antibody (CAB2296) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
