SRGAP3 Antibody (PACO57992)
- SKU:
- PACO57992
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SRGAP3 Antibody (PACO57992)
The SRGAP3 Polyclonal Antibody (PAC057992) is a valuable tool for researchers studying SRGAP3, a key protein involved in neuronal development and synaptic function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the SRGAP3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for neurobiology and neuroscience studies.SRGAP3, also known as SLIT-ROBO Rho GTPase Activating Protein 3, plays a crucial role in the development and plasticity of synapses in the brain.
Its involvement in neuronal signaling pathways makes it a promising target for research into neurological disorders, such as autism, schizophrenia, and intellectual disabilities. Understanding the function of SRGAP3 is essential for uncovering new therapeutic targets and potential treatments for these conditions.Overall, the SRGAP3 Polyclonal Antibody is a reliable tool for investigating the role of SRGAP3 in neuronal development and synaptic function, offering valuable insights into the molecular mechanisms underlying brain disorders and potential therapeutic interventions.
| Antibody Name: | SRGAP3 Antibody (PACO57992) |
| Antibody SKU: | PACO57992 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human SLIT-ROBO Rho GTPase-activating protein 3 protein (709-955AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of A549 cells with PACO57992 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. |
| Synonyms: | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP), SRGAP3, ARHGAP14 KIAA0411 KIAA1156 MEGAP SRGAP2 |
| UniProt Protein Function: | ARHGAP14: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation. Translocation t(X;3)(p11.2;p25). 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; Rac GTPase binding Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of cell migration |
| UniProt Code: | O43295 |
| NCBI GenInfo Identifier: | 48429207 |
| NCBI Gene ID: | 9901 |
| NCBI Accession: | O43295.3 |
| UniProt Secondary Accession: | O43295,Q8IX13, Q8IZV8, |
| UniProt Related Accession: | O43295 |
| Molecular Weight: | 1099 |
| NCBI Full Name: | SLIT-ROBO Rho GTPase-activating protein 3 |
| NCBI Synonym Full Names: | SLIT-ROBO Rho GTPase activating protein 3 |
| NCBI Official Symbol: | SRGAP3Â Â |
| NCBI Official Synonym Symbols: | WRP; MEGAP; SRGAP2; ARHGAP14Â Â |
| NCBI Protein Information: | SLIT-ROBO Rho GTPase-activating protein 3; mental disorder-associated GAP; rho GTPase-activating protein 14; SLIT-ROBO Rho GTPase activating protein 2; WAVE-associated Rac GTPase activating protein |
| UniProt Protein Name: | SLIT-ROBO Rho GTPase-activating protein 3 |
| UniProt Synonym Protein Names: | Mental disorder-associated GAP; Rho GTPase-activating protein 14; WAVE-associated Rac GTPase-activating protein; WRP |
| Protein Family: | SLIT-ROBO Rho GTPase-activating protein |
| UniProt Gene Name: | SRGAP3Â Â |
| UniProt Entry Name: | SRGP3_HUMAN |
| Antibodies |
| SRGAP3 Antibody (PACO12458) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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