The SRGAP3 Polyclonal Antibody (PAC017144) is a valuable tool for researchers studying the SRGAP3 protein, a key regulator of neuronal development and synaptic function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the SRGAP3 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component for studies in neuroscience and neurodevelopmental disorders.SRGAP3, also known as Slit-Robo Rho GTPase activating protein 3, plays a crucial role in neuronal migration, axon guidance, and synaptic plasticity.
Dysregulation of SRGAP3 has been linked to neurological conditions such as autism spectrum disorders and intellectual disabilities. Research on SRGAP3 is essential for uncovering the molecular mechanisms underlying these disorders and developing targeted therapies.By using the SRGAP3 Polyclonal Antibody, researchers can gain insights into the function and regulation of SRGAP3 in normal and pathological conditions, paving the way for potential advances in the diagnosis and treatment of neurological disorders.
Antibody Name:
SRGAP3 Antibody (PACO17144)
Antibody SKU:
PACO17144
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human SRGAP3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17144(SRGAP3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO17144(SRGAP3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
SRGAP3 is a 1099 amino acid, protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Synonyms:
SLIT-ROBO Rho GTPase activating protein 3
UniProt Protein Function:
ARHGAP14: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation. Translocation t(X;3)(p11.2;p25). 3 isoforms of the human protein are produced by alternative splicing.
Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of cell migration
