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SRGAP3 Antibody (PACO12458)

SKU:
PACO12458
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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SRGAP3 Antibody (PACO12458)

The SRGAP3 Polyclonal Antibody (PACO12458) is a valuable tool for researchers studying the SRGAP3 protein, which is involved in neuronal development and synaptic plasticity. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot experiments. By binding to the SRGAP3 protein, it allows for the detection and analysis of this important molecule in various cell types, making it an essential tool for neuroscience and neurobiology research.SRGAP3, also known as Slit-Robo Rho GTPase-activating protein 3, is crucial for proper brain development and function, particularly in the regulation of neuronal migration and connectivity.

Dysregulation of SRGAP3 has been linked to neurodevelopmental disorders and cognitive deficits, underscoring the importance of studying this protein in both normal and pathological conditions. By understanding the role of SRGAP3 in the brain, researchers can gain insights into potential therapeutic targets for neurological diseases and disorders.Overall, the SRGAP3 Polyclonal Antibody (PACO12458) is a reliable reagent for investigating the function and regulation of SRGAP3 in various experimental settings, paving the way for advancements in neuroscience and neurology research.

Antibody Name:SRGAP3 Antibody (PACO12458)
Antibody SKU:PACO12458
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human SRGAP3
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:SLIT-ROBO Rho GTPase activating protein 3;SRGAP3;ARHGAP14;KIAA0411;MEGAP;SRGAP2;WRP ;
UniProt Protein Function:ARHGAP14: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation. Translocation t(X;3)(p11.2;p25). 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cytoplasm; cytosol

Molecular Function:protein binding; Rac GTPase binding

Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of cell migration

UniProt Code:O43295
NCBI GenInfo Identifier:48429207
NCBI Gene ID:9901
NCBI Accession:O43295.3
UniProt Secondary Accession:O43295,Q8IX13, Q8IZV8,
UniProt Related Accession:O43295
Molecular Weight:1099
NCBI Full Name:SLIT-ROBO Rho GTPase-activating protein 3
NCBI Synonym Full Names:SLIT-ROBO Rho GTPase activating protein 3
NCBI Official Symbol:SRGAP3  
NCBI Official Synonym Symbols:WRP; MEGAP; SRGAP2; ARHGAP14  
NCBI Protein Information:SLIT-ROBO Rho GTPase-activating protein 3; mental disorder-associated GAP; rho GTPase-activating protein 14; SLIT-ROBO Rho GTPase activating protein 2; WAVE-associated Rac GTPase activating protein
UniProt Protein Name:SLIT-ROBO Rho GTPase-activating protein 3
UniProt Synonym Protein Names:Mental disorder-associated GAP; Rho GTPase-activating protein 14; WAVE-associated Rac GTPase-activating protein; WRP
Protein Family:SLIT-ROBO Rho GTPase-activating protein
UniProt Gene Name:SRGAP3  
UniProt Entry Name:SRGP3_HUMAN

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