| UniProt Protein Function: | SRGAP2C: Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory. Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 functionChromosomal Location of Human Ortholog: 1p11.2Molecular Function: protein homodimerization activity; protein heterodimerization activityBiological Process: extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; negative regulation of filopodium formation |
| UniProt Protein Details: | |
| NCBI Summary: | This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012] |
| UniProt Code: | P0DMP2 |
| NCBI GenInfo Identifier: | 862669365 |
| NCBI Gene ID: | 647135 |
| NCBI Accession: | NP_001258799 |
| UniProt Secondary Accession: | P0DMP2 |
| UniProt Related Accession: | P0DMP2 |
| Molecular Weight: | 53 kDa |
| NCBI Full Name: | SLIT-ROBO Rho GTPase-activating protein 2B isoform 1 |
| NCBI Synonym Full Names: | SLIT-ROBO Rho GTPase activating protein 2B |
| NCBI Official Symbol: | SRGAP2BÂ Â |
| NCBI Official Synonym Symbols: | SRGAP2L; SRGAP2P2Â Â |
| NCBI Protein Information: | SLIT-ROBO Rho GTPase-activating protein 2B |
| UniProt Protein Name: | SLIT-ROBO Rho GTPase-activating protein 2C |
| UniProt Synonym Protein Names: | SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1 |
| Protein Family: | SLIT-ROBO Rho GTPase-activating protein |
| UniProt Gene Name: | SRGAP2CÂ Â |
| UniProt Entry Name: | SRG2C_HUMAN |
