The SRGAP2B Antibody (PAC047842) is a powerful tool for researchers studying the SRGAP2B protein, a key regulator of neuronal development and synaptic plasticity. This polyclonal antibody is raised in rabbits and exhibits high reactivity with human samples, making it ideal for use in Western blot applications. By binding specifically to the SRGAP2B protein, this antibody enables accurate detection and analysis in various cell types, providing valuable insights into neuronal function and potential therapeutic targets.
SRGAP2B is known for its role in neuronal development, particularly in regulating dendritic spine growth and synaptic transmission. Dysfunction of SRGAP2B has been implicated in neurological disorders such as autism spectrum disorders and intellectual disabilities, making it a promising target for further investigation. By understanding the mechanisms by which SRGAP2B influences synaptic plasticity, researchers can potentially uncover new therapeutic strategies for these conditions.
Western Blot. Positive WB detected in: Mouse heart tissue. All lanes: SRGAP2B antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 54 kDa. Observed band size: 54 kDa..
Immunofluorescent analysis of MCF-7 cells using PACO47842 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.
Synonyms:
SLIT-ROBO Rho GTPase-activating protein 2B (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2), SRGAP2B, SRGAP2P2
UniProt Protein Function:
SRGAP2C: Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory. Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 functionChromosomal Location of Human Ortholog: 1p11.2Molecular Function: protein homodimerization activity; protein heterodimerization activityBiological Process: extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; negative regulation of filopodium formation
UniProt Protein Details:
NCBI Summary:
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012]
