SRF Transcription Factor Activity Assay

SKU:

TFAB00164

Product Type:

ELISA Kit

ELISA Type:

Transcription Factor Assay

Analytes:

SRF

Reactivity:

Human

Mouse

Description

Description

Datasheet

SRF Transcription Factor Activity Assay

The SRF Transcription Factor Activity Assay Kit is a cutting-edge tool for researchers to accurately measure the activity of the serum response factor (SRF) transcription factor in cell lysates. This innovative kit offers high sensitivity and specificity, allowing for precise and reliable results in a variety of research applications.SRF is a key regulator of gene expression, playing a critical role in cell growth, differentiation, and motility. By measuring SRF activity, researchers can gain valuable insights into the molecular mechanisms underlying various physiological and pathological processes, including cancer, cardiovascular diseases, and neurological disorders.

With the SRF Transcription Factor Activity Assay Kit, researchers can uncover new pathways and potential therapeutic targets for a range of diseases. This kit is designed to streamline the assay process, saving time and resources while delivering accurate and reproducible data. Elevate your research with the SRF Transcription Factor Activity Assay Kit from AssayGenie.

UniProt Protein Function:	SRF: a transcription factor of the MADS domain family that binds to the serum response element (SRE). Regulates the transcription of immediate early genes including c-fos. Binds DNA as a multimer, probably a dimer.
UniProt Protein Details:	Protein type:Transcription factor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus Molecular Function:chromatin DNA binding; histone deacetylase binding; protein binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity; transcription factor binding Biological Process: angiogenesis involved in wound healing; associative learning; cardiac myofibril assembly; cell migration during sprouting angiogenesis; cell-matrix adhesion; developmental growth; erythrocyte development; heart development; heart looping; hippocampus development; long-term memory; mesoderm formation; morphogenesis of an epithelial sheet; mRNA transcription from RNA polymerase II promoter; muscle maintenance; negative regulation of cell migration; negative regulation of cell proliferation; neurite development; neuron development; neuron migration; patterning of blood vessels; platelet activation; platelet formation; positive regulation of axon extension; positive regulation of cell differentiation; positive regulation of filopodium formation; positive regulation of smooth muscle contraction; positive regulation of transcription by glucose; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive thymic T cell selection; regulation of cell adhesion; regulation of smooth muscle cell differentiation; regulation of water loss via skin; response to cytokine stimulus; response to hormone stimulus; response to hypoxia; response to toxin; sarcomere organization; skin morphogenesis; small GTPase mediated signal transduction; stress fiber formation; tangential migration from the subventricular zone to the olfactory bulb; thymus development; thyroid gland development; transcription from RNA polymerase II promoter; trophectodermal cell differentiation
NCBI Summary:	This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
UniProt Code:	P11831
NCBI GenInfo Identifier:	134876
NCBI Gene ID:	6722
NCBI Accession:	P11831.1
UniProt Secondary Accession:	P11831,Q5T648,
UniProt Related Accession:	P11831
Molecular Weight:	51,593 Da
NCBI Full Name:	Serum response factor
NCBI Synonym Full Names:	serum response factor
NCBI Official Symbol:	SRF
NCBI Official Synonym Symbols:	MCM1
NCBI Protein Information:	serum response factor
UniProt Protein Name:	Serum response factor
Protein Family:	Serum response factor
UniProt Gene Name:	SRF
UniProt Entry Name:	SRF_HUMAN