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SRF Rabbit Polyclonal Antibody (CAB7731)

SKU:
CAB7731
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-SRF Antibody CAB7731
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-SRF Antibody CAB7731
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-SRF Antibody CAB7731
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-SRF Antibody CAB7731
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:SRF Rabbit Polyclonal Antibody
SKU:CAB7731
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 321-420 of human SRF (NP_003122.1).
Sequence:TVLK STGS GPVS SGGL MQLP TSFT LMPG GAVA QQVP VQAI QVHQ APQQ ASPS RDSS TDLT QTSS SGTV TLPA TIMT SSVP TTVG GHMM YPSP HAVM YAPT
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:MCM1; SRF
Positive Sample:A-431,NIH/3T3,C6
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:52kDa
Observed MW:67kDa

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:6722
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from A-431 cells, using SRF Rabbit pAb (CAB7731) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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