The SRF Polyclonal Antibody (CAB16718) is a valuable tool for researchers studying Serum Response Factor (SRF) in various biological processes. SRF is a transcription factor that plays a crucial role in the regulation of genes involved in cell growth, differentiation, and tissue remodeling. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting SRF in human samples, making it ideal for Western blot applications.By targeting SRF, researchers can gain insights into its function and signaling pathways, particularly in the context of cancer, cardiovascular diseases, and neurological disorders.
The SRF Polyclonal Antibody facilitates the detection and analysis of SRF expression in different cell types, enabling researchers to explore its role in various physiological and pathological conditions. Overall, this antibody is a valuable asset for studies in molecular biology, cell biology, and disease research.
Product Name:
SRF Rabbit Polyclonal Antibody
SKU:
CAB16718
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SRF (NP_003122.1).
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6722
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SRF Rabbit pAb (CAB16718) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
