The SREBF1 Polyclonal Antibody (CAB15586) is a powerful tool for researching SREBF1, a key transcription factor involved in the regulation of lipid metabolism and cellular growth. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting SREBF1 in human samples, making it ideal for use in Western blot applications.SREBF1, also known as sterol regulatory element binding transcription factor 1, plays a crucial role in the control of cholesterol and fatty acid synthesis in cells. Dysregulation of SREBF1 has been implicated in various metabolic disorders, including obesity, diabetes, and cardiovascular diseases.
By targeting SREBF1, researchers can gain valuable insights into the mechanisms underlying these conditions and explore potential therapeutic interventions.With its ability to specifically bind to SREBF1, this polyclonal antibody enables researchers to investigate the expression levels and activity of the transcription factor in different cell types and experimental conditions. By understanding the role of SREBF1 in lipid metabolism and cellular growth, researchers can uncover new avenues for drug development and personalized medicine approaches in the treatment of metabolic diseases.
Product Name:
SREBP1 Rabbit Polyclonal Antibody
SKU:
CAB15586
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-310 of human SREBF1 (NP_004167.3).
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively.
Purification Method:
Affinity purification
Gene ID:
6720
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat liver using SREBF1 Rabbit pAb(CAB15586) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
