SREBP1 Rabbit Polyclonal Antibody (CAB15586)
- SKU:
- CAB15586
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | SREBP1 Rabbit Polyclonal Antibody |
SKU: | CAB15586 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-310 of human SREBF1 (NP_004167.3). |
Sequence: | SLHT QVQS VVPQ QLLT VTAA PTAA PVTT TVTS QIQQ VPVL LQPH FIKA DSLL LTAM KTDG ATVK AAGL SPLV SGTT VQTG PLPT LVSG GTIL ATVP LVVD AEKL PINR LAA |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | HMD; IFAP2; SREBP1; bHLHd1; SREBF1 |
Positive Sample: | Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | COPII-coated vesicle membrane, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein, Multi-pass membrane protein, Nucleus. |
Calculated MW: | 122kDa |
Observed MW: | 68kDa |
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively.
Purification Method: | Affinity purification |
Gene ID: | 6720 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |