Anti-SRCIN1 Antibody (PACO22761)

SRCIN1 Antibody (PACO22761)

SKU:

PACO22761

Product Type:

Antibody

Reactivity:

Human

Host Species:

Rabbit

Isotype:

IgG

Applications:

ELISA

Antibody Type:

Polyclonal Antibody

Conjugation:

Unconjugated

Description

Description

DatasheetMSDS

SRCIN1 Antibody (PACO22761)

The SRCIN1 Polyclonal Antibody (PAC02761) is a valuable tool for researchers studying SRCIN1, a protein involved in cellular processes and signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SRCIN1 protein, this antibody enables the detection and analysis of SRCIN1 in various cell types, making it ideal for studies in molecular biology and cancer research.SRCIN1, also known as a regulator of integrin activity, plays a crucial role in cell adhesion, migration, and invasion processes.

Its involvement in these key cellular functions makes it a promising target for research into cancer metastasis and tumor progression. By elucidating the mechanisms by which SRCIN1 functions, researchers can gain valuable insights into potential therapeutic strategies for combating cancer and other diseases associated with aberrant cell signaling pathways.

SRCIN1 Antibody (PACO06718)

$323

Product Code:

PACO06718

Isotype:

IgG

Antibody Type:

Polyclonal Antibody

Immunofluorescence staining of MCF-7 cells with PACO64925 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). — Choose Options

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RIMS4 Antibody (PACO64925)

$383

Product Code:

PACO64925

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Western Blot<br />
Positive WB detected in: Mouse heart tissue,Mouse kidney tissue<br />
All lanes: ompF antibody at 1:2000<br />
Secondary<br />
Goat polyclonal to rabbit IgG at 1/50000 dilution<br />
Predicted band size: 57 kDa<br />
Observed band size: 57 kDa<br /> — Choose Options

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Ang4 Antibody (PACO64593)

$407

Product Code:

PACO64593

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Immunofluorescence staining of NIH/3T3 cells with PACO64869 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). — Choose Options

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OR13C8 Antibody (PACO64869)

$383

Product Code:

PACO64869

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Immunofluorescence staining of Hela cells with PACO64949 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). — Choose Options

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SIM1 Antibody (PACO64949)

$407

Product Code:

PACO64949

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Western Blot<br />
Positive WB detected in: Escherichia coli lysate<br />
All lanes: OTSB antibody at 1:2000<br />
Secondary<br />
Goat polyclonal to rabbit IgG at 1/50000 dilution<br />
Predicted band size: 30 kDa<br />
Observed band size: 30 kDa<br /> — Choose Options

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otsB Antibody (PACO64885)

$407

Product Code:

PACO64885

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

IHC image of PACO64929 diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. — Choose Options

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RNF122 Antibody (PACO64929)

$383

Product Code:

PACO64929

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Immunofluorescence staining of SH-SY5Y cells with PACO64589-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). — Choose Options

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AGO4 Antibody (PACO64589)

$383

Product Code:

PACO64589

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

IHC image of PACO64729 diluted at 1:200 and staining in paraffin-embedded rat kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. — Choose Options

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Fn1 Antibody (PACO64729)

$407

Product Code:

PACO64729

Isotype:

IgG

Antibody Name:	SRCIN1 Antibody (PACO22761)
Antibody SKU:	PACO22761
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human SNIP.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:	Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Synonyms:	p130Cas-associated protein; P140; p140Cap; SNAP-25-interacting protein;

UniProt Protein Function:	SNIP: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Interacts with the N-terminal coiled-coil region of SNAP25. Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3. Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. Belongs to the SRCIN1 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 17q12Cellular Component: postsynaptic membrane; focal adhesion; axon; cytoplasm; dendrite; postsynaptic density; synapse; actin cytoskeletonMolecular Function: protein binding; protein kinase bindingBiological Process: exocytosis; regulation of cell migration
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q9C0H9
NCBI GenInfo Identifier:	115334682
NCBI Gene ID:	80725
NCBI Accession:	NP_079524.2
UniProt Secondary Accession:	Q9C0H9,Q75T46, Q8N4W8
UniProt Related Accession:	Q9C0H9
Molecular Weight:	112,453 Da
NCBI Full Name:	SRC kinase signaling inhibitor 1
NCBI Synonym Full Names:	SRC kinase signaling inhibitor 1
NCBI Official Symbol:	SRCIN1
NCBI Official Synonym Symbols:	P140; SNIP
NCBI Protein Information:	SRC kinase signaling inhibitor 1; p140Cap; P130Cas-associated protein; SNAP25-interacting protein; SNAP-25-interacting protein
UniProt Protein Name:	SRC kinase signaling inhibitor 1
UniProt Synonym Protein Names:	SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap
Protein Family:
UniProt Gene Name:	SRCIN1
UniProt Entry Name:	SRCN1_HUMAN

SRCIN1 Antibody (PACO22761)

Description

SRCIN1 Antibody (PACO22761)

Overview

Properties

Product Images

Additional Information

Related Products

SRCIN1 Antibody (PACO22761)

Description

SRCIN1 Antibody (PACO22761)

Overview

Properties

Product Images

Additional Information

Related Products

Related Products

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