SQSTM1 Polyclonal Antibody (CAB22025)
- SKU:
- CAB22025
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | SQSTM1 Polyclonal Antibody |
SKU: | CAB22025 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of mouse SQSTM1 (NP_035148.1). |
Sequence: | PLGI EVDI DVEH GGKR SRLT PTTP ESSS TGTE DKSN TQPS SCSS EVSK PDGA GEGP AQSL TEQM KKIA LESV GQPE EQME SGNC SGGD DDWT HLSS KEVD P |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | Osi; p62; A170; STAP; OSF-6; STONE14; SQSTM1 |
Positive Sample: | HeLa,293T,PC-12,C2C12+chloroquine |
Conjugate: | Unconjugated |
Cellular Localization: | amphisome, autophagosome, cytoplasm, cytosol, endoplasmic reticulum, late endosome, mitochondrion, P-body, PML body, sarcomere |
Calculated MW: | 48kDa |
Observed MW: | 62kDa |
Enables K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including brown fat cell proliferation; energy homeostasis; and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome; autolysosome; and sperm midpiece. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1).
Purification Method: | Affinity purification |
Gene ID: | 18412 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |