The SQSTM1 Polyclonal Antibody (AB10001) is a valuable tool for researchers studying SQSTM1, a protein involved in a variety of cellular processes including selective autophagy and inflammation. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to SQSTM1, this antibody allows for precise detection and analysis of the protein in different cell types, making it ideal for research in the fields of autophagy, inflammation, and cancer biology.SQSTM1, also known as sequestosome 1, plays a key role in cell homeostasis by targeting damaged or unwanted proteins for degradation through autophagy.
Dysregulation of SQSTM1 has been linked to various diseases, including neurodegenerative disorders and cancer. By understanding the function of SQSTM1, researchers can gain insights into the mechanisms underlying these conditions and potentially develop targeted therapies to treat them.Overall, the SQSTM1 Polyclonal Antibody is a valuable tool for researchers looking to explore the role of SQSTM1 in health and disease. Its specificity and reliability make it a trusted reagent for studies aiming to elucidate the complex functions of this important protein.
Product Name:
SQSTM1 Polyclonal Antibody
SKU:
CAB22025
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of mouse SQSTM1 (NP_035148.1).
Enables K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including brown fat cell proliferation; energy homeostasis; and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome; autolysosome; and sperm midpiece. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1).
Purification Method:
Affinity purification
Gene ID:
18412
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SQSTM1 Rabbit pAb (CAB22025) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
