null

SQSTM1/p62 Polyclonal Antibody (CAB21787)

SKU:
CAB21787
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
€129 - €359
Frequently bought together:

Description

SQSTM1/p62 Polyclonal Antibody (CAB21787)

The SQSTM1/p62 Polyclonal Antibody (CAB21787) is a powerful tool for research involving SQSTM1/p62, a protein involved in various cellular processes such as selective autophagy and signal transduction. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. It binds specifically to the SQSTM1/p62 protein, allowing for accurate detection and analysis across different cell types, making it ideal for studies in cell biology and disease research.

SQSTM1/p62 plays a crucial role in maintaining cellular homeostasis by targeting damaged or misfolded proteins for degradation through autophagy. Dysregulation of SQSTM1/p62 has been implicated in various diseases including neurodegenerative disorders, cancer, and metabolic syndromes. Research into the function of SQSTM1/p62 is vital for developing targeted therapies to treat these diseases by restoring autophagic processes and promoting cellular health.

Product Name:SQSTM1/p62 Polyclonal Antibody
Product Code:CAB21787
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Cellular Location:Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Late endosome, Lysosome, Nucleus, P-body, autophagosome

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-440 of human SQSTM1/p62 (NP_003891.1).
Sequence:HLSSK EVDPS TGELQ SLQMP ESEGP SSLDP SQEGP TGLKE AALYP HLPPE ADPRL IESLS QMLSM GFSDE GGWLT RLLQT KNYDI GAALD TIQYS KHPPP L
Synonyms:p60, p62, A170, DMRV, OSIL, PDB3, ZIP3, p62B, NADGP, FTDALS3
Calculated MW:48kDa
Observed MW:Refer to figures

Related Products