null

SQSTM1/p62 Polyclonal Antibody (CAB21702)

SKU:
CAB21702
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
IP
€139 - €529
Frequently bought together:

Description

SQSTM1/p62 Polyclonal Antibody (CAB21702)

The SQSTM1/p62 Polyclonal Antibody (CAB21702) is a valuable tool for researchers studying SQSTM1/p62, a multifunctional protein involved in various cellular processes such as autophagy, protein turnover, and signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.SQSTM1/p62, also known as sequestosome-1, plays a crucial role in selective autophagy by recognizing and targeting ubiquitinated proteins for degradation. Dysregulation of SQSTM1/p62 has been implicated in various diseases, including neurodegenerative disorders, cancer, and inflammatory conditions.

Therefore, understanding the function and regulation of SQSTM1/p62 is essential for developing targeted therapies and interventions for these diseases.With the SQSTM1/p62 Polyclonal Antibody (CAB21702), researchers can accurately detect and analyze SQSTM1/p62 protein levels in different cell types, making it an ideal tool for studies in molecular biology, cell biology, and disease mechanisms. By investigating the role of SQSTM1/p62 in various cellular processes and disease states, this antibody can provide valuable insights for advancing our understanding of pathophysiology and developing novel therapeutic strategies.

Product Name:SQSTM1/p62 Polyclonal Antibody
Product Code:CAB21702
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, IP, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation
Recommended Dilution:WB 1:2000-1:4000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200, IP 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:293T, HeLa, L929, PC-12
Cellular Location:Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Late endosome, Lysosome, Nucleus, P-body, autophagosome

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-440 of human SQSTM1/p62. (NP_003891.1).
Sequence:HLSSK EVDPS TGELQ SLQMP ESEGP SSLDP SQEGP TGLKE AALYP HLPPE ADPRL IESLS QMLSM GFSDE GGWLT RLLQT KNYDI GAALD TIQYS KHPPP L
Synonyms:p60, p62, A170, DMRV, OSIL, PDB3, ZIP3, p62B, NADGP, FTDALS3
Calculated MW:48kDa
Observed MW:62kDa

Related Products