The SPTBN2 Polyclonal Antibody (PAC012445) is a valuable tool for researchers studying SPTBN2, a cytoskeletal protein involved in cell shape, motility, and signaling pathways. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blotting applications.SPTBN2, also known as β-III spectrin, plays a crucial role in maintaining cell structure and function, particularly in neurons and muscle cells. Dysregulation of SPTBN2 has been linked to various neurological disorders and muscle diseases, making it a promising target for therapeutic interventions.
By specifically binding to the SPTBN2 protein, this antibody enables precise detection and analysis in different cell types, offering insights into the function and regulation of SPTBN2 in various physiological and pathological conditions. Whether investigating neurodegenerative diseases, muscular dystrophies, or cell signaling mechanisms, the SPTBN2 Polyclonal Antibody is an essential tool for advancing research in these fields.
Probably plays an important role in neuronal membrane skeleton.
UniProt Protein Details:
NCBI Summary:
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
