The SPTBN1 Polyclonal Antibody (CAB5253) is a valuable tool for researchers studying the SPTBN1 protein, also known as Spectrin beta, Non-Erythrocytic 1. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it suitable for a variety of research applications.SPTBN1 is a key cytoskeletal protein involved in maintaining cell shape and structure, as well as playing a role in cell adhesion and migration. Dysregulation of SPTBN1 has been linked to various diseases, including cancer and neurological disorders. The CAB5253 antibody binds specifically to the SPTBN1 protein, enabling researchers to detect and analyze its expression in different cell types.
By studying the function and regulation of SPTBN1, researchers can gain insights into its role in cellular processes and disease development. This antibody is validated for use in Western blot applications, making it a valuable tool for studies in cell biology, cancer research, and neurology. Its high specificity and reactivity with human samples make it a reliable choice for researchers looking to explore the functions of SPTBN1 in health and disease.
Product Name:
SPTBN1 Rabbit Polyclonal Antibody
SKU:
CAB5253
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2100-2200 of human SPTBN1 (NP_003119.2).
Sequence:
PPSP EPST KVSE EAES QQQW DTSK GEQV SQNG LPAE QGSP RMAE TVDT SEMV NGAT EQRT SSKE SSPI PSPT SDRK AKTA LPAQ SAAT LPAR TQET PSAQ M
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6711
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SPTBN1 Rabbit pAb (CAB5253) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
