The SPTAN1 Polyclonal Antibody (CAB0160) is a valuable tool for researchers studying the spectrin alpha chain, non-erythrocytic 1 (SPTAN1) protein. This antibody, developed using rabbits as the host species, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications.SPTAN1 is a crucial component of the spectrin cytoskeleton, playing a key role in maintaining cell shape and membrane stability. Mutations in the SPTAN1 gene have been associated with neurodevelopmental disorders and neurodegenerative diseases, making it an intriguing target for further investigation.
By specifically binding to the SPTAN1 protein, this antibody enables precise detection and analysis of SPTAN1 levels in various cell types. Its utility in immunology and neuroscience research makes it an essential tool for studying the function and dysfunction of the spectrin cytoskeleton in health and disease.Overall, the SPTAN1 Polyclonal Antibody provides researchers with a reliable means of exploring the diverse roles of SPTAN1 in cellular physiology and pathology, paving the way for new insights and potential therapeutic strategies in the field of neuroscience and beyond.
Product Name:
Alpha Fodrin Rabbit Polyclonal Antibody
SKU:
CAB0160
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 950-1130 of human Alpha Fodrin (NP_001123910.1).
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6709
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Alpha Fodrin Rabbit pAb (CAB0160) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
