alpha 1 Spectrin Rabbit Polyclonal Antibody (CAB12355)
- SKU:
- CAB12355
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | alpha 1 Spectrin Rabbit Polyclonal Antibody |
SKU: | CAB12355 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 940-1160 of human alpha 1 Spectrin (NP_003117.2). |
Sequence: | KHEA FLLD LNSF GDSM KALR NQAN ACQQ QQAA PVEG VAGE QRVM ALYD FQAR SPRE VTMK KGDV LTLL SSIN KDWW KVEA ADHQ GIVP AVYV RRLA HDEF PMLP QRRR EEPG NITQ RQEQ IENQ YRSL LDRA EERR RRLL QRYN EFLL AYEA GDML EWIQ EKKA ENTG VELD DVWE LQKK FDEF QKDL NTNE PRLR DINK VADD LLFE GLLT PEGA QIRQ E |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | EL2; HPP; HS3; SPH3; SPTA; alpha 1 Spectrin |
Positive Sample: | 239T,LO2,A-549,Mouse kidney,Mouse liver,Mouse lung,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cell cortex, cytoskeleton. |
Calculated MW: | 280kDa |
Observed MW: | 300kDa |
This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3.
Purification Method: | Affinity purification |
Gene ID: | 6708 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |