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SPRY2 Antibody (PACO50038)

SKU:
PACO50038
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SPRY2 Antibody PACO50038
  • SPRY2 Antibody PACO50038
  • SPRY2 Antibody PACO50038
€359

Description

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SPRY2 Antibody (PACO50038)

The SPRY2 Polyclonal Antibody (PAC050038) is a valuable tool for researchers studying SPRY2, a protein involved in various cellular processes such as cell growth, differentiation, and survival. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the SPRY2 protein, allowing for accurate detection and analysis in different cell types.SPRY2 is known to be a key player in signaling pathways that regulate cell proliferation and migration, making it a potential target for cancer research and drug development.

By understanding the functions of SPRY2, researchers can unravel its role in tumorigenesis and potentially identify new therapeutic strategies for cancer treatment.The SPRY2 Polyclonal Antibody is an essential tool for investigating the molecular mechanisms involving SPRY2, offering valuable insights into its function and potential implications in disease pathology. Its application in immunology and cancer research makes it a versatile antibody for a wide range of studies in the field.

Antibody Name:SPRY2 Antibody (PACO50038)
Antibody SKU:PACO50038
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human, Mouse
Immunogen:Recombinant Human SPRY2 protein (2-97AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: NIH/3T3 whole cell lysate, Jurkat whole cell lysate, HEK293 whole cell lysate. All lanes: SPRY2 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40 kDa. Observed band size: 40 kDa..
Product ImageImmunofluorescent analysis of HepG2 cells using PACO50038 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human brain tissue using PACO50038 at dilution of 1:100.
Background:May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Synonyms:Protein sprouty homolog 2 (Spry-2), SPRY2
UniProt Protein Function:SPRY2: a feedback inhibitor of growth factor receptor signaling. Belongs to the sprouty family. May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; InhibitorChromosomal Location of Human Ortholog: 13q31.1Cellular Component: microtubule cytoskeleton; microtubule; plasma membrane; cytosolMolecular Function: protein serine/threonine kinase inhibitor activity; protein serine/threonine kinase activator activity; protein binding; protein kinase bindingBiological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; cell fate commitment; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of nerve growth factor receptor signaling pathway; positive regulation of peptidyl-serine phosphorylation; negative regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; sensory perception of sound; establishment of mitotic spindle orientation; negative regulation of Ras protein signal transduction; negative regulation of apoptosis
UniProt Protein Details:
NCBI Summary:This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq]
UniProt Code:Q7Z783
NCBI GenInfo Identifier:2809400
NCBI Gene ID:10253
NCBI Accession:
UniProt Secondary Accession:Q7Z783,Q5T6Z7
UniProt Related Accession:Q7Z783,O43597, Q7Z783
Molecular Weight:34,688 Da
NCBI Full Name:Sprouty 2
NCBI Synonym Full Names:sprouty homolog 2 (Drosophila)
NCBI Official Symbol:SPRY2  
NCBI Official Synonym Symbols:hSPRY2; MGC23039  
NCBI Protein Information:protein sprouty homolog 2; spry-2; sprouty 2; OTTHUMP00000018543
UniProt Protein Name:Protein sprouty homolog 2
UniProt Synonym Protein Names:
Protein Family:Protein sprouty
UniProt Gene Name:SPRY2  
UniProt Entry Name:SPY2_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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