The SPRTN Polyclonal Antibody (CAB11663) is a valuable tool for researchers studying the SPRTN protein, a key regulator of DNA repair and genome stability. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting SPRTN in human samples, particularly in Western blot applications. By targeting the SPRTN protein, researchers can explore its role in DNA repair mechanisms and its potential implications in cancer research and genetic diseases.SPRTN, also known as Spartan, is a key player in the DNA damage response pathway, playing a crucial role in maintaining genomic integrity and preventing the accumulation of DNA damage.
Dysregulation of SPRTN has been linked to various diseases, including neurodegenerative disorders and cancer, making it a promising target for therapeutic interventions. Understanding the function of SPRTN is essential for developing novel treatment strategies that target DNA repair pathways and promote genome stability.
Product Name:
SPRTN Rabbit Polyclonal Antibody
SKU:
CAB11663
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SPRTN (NP_001010984.1).
The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified.
Purification Method:
Affinity purification
Gene ID:
83932
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using SPRTN Rabbit pAb (CAB11663) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
