SPRTN Rabbit Polyclonal Antibody (CAB11620)
- SKU:
- CAB11620
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | SPRTN Rabbit Polyclonal Antibody |
SKU: | CAB11620 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SPRTN (NP_001010984.1). |
Sequence: | MDDD LMLA LRLQ EEWN LQEA ERDH AQES LSLV DASW ELVD PTPD LQAL FVQF NDQF FWGQ LEAV EVKW SVRM TLCA GICS YEGK GGMC SIRL SEPL LKLR PRKD LVET LLHE MIHA YLFV TNND KDRE GHGP EFCK HMHR INSL TGAN ITVY HTFH DEVD EYRR HWWR CNGP CQHR PPYY GYVK RATN REPS AHDY WWAE HQKT CGGT YIKI KEPE NYSK KGKG KAKL GKEP VLAA ENKG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DVC1; PRO4323; spartan; C1orf124; SPRTN |
Positive Sample: | U-87MG |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus. |
Calculated MW: | 55kDa |
Observed MW: | 60kDa |
The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified.
Purification Method: | Affinity purification |
Gene ID: | 83932 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |