The SPRTN Polyclonal Antibody (CAB11620) is a valuable tool for researchers studying the SPRTN protein, a key player in DNA repair and genome stability. This antibody, produced in rabbits, exhibits high reactivity with samples from various species and has been validated for use in Western blot applications. By binding to the SPRTN protein, this antibody enables researchers to detect and analyze SPRTN expression in different cell types, making it ideal for studies in genetics and cancer research.SPRTN, also known as Spartan, is a critical enzyme involved in DNA damage response pathways, specifically dealing with the repair of DNA lesions and maintaining genome integrity.
Mutations in the SPRTN gene have been linked to increased susceptibility to certain types of cancer and other genetic disorders. Understanding the function of SPRTN is essential for developing targeted therapies that can exploit its role in DNA repair mechanisms for the treatment of diseases related to genomic instability. By utilizing the SPRTN Polyclonal Antibody (CAB11620), researchers can gain valuable insights into the mechanisms underlying DNA repair and genome stability, paving the way for advancements in personalized medicine and precision oncology.
Product Name:
SPRTN Rabbit Polyclonal Antibody
SKU:
CAB11620
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SPRTN (NP_001010984.1).
The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified.
Purification Method:
Affinity purification
Gene ID:
83932
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from U-87MG cells, using SPRTN Rabbit pAb (CAB11620) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
