The SPOP-L Antibody (PAC057988) is a highly specific and sensitive tool for research involving the SPOP-L protein, a key player in cancer biology and potential therapeutic target. This polyclonal antibody, produced in rabbits, is optimized for detection in human samples and validated for use in Western blot applications. It binds specifically to the SPOP-L protein, allowing for precise detection and analysis in various cell types, making it an excellent choice for studies in oncology and drug development research.SPOP-L, a member of the speckle-type POZ protein family, is known for its involvement in the regulation of protein degradation and cellular signaling pathways related to cancer progression.
Its role in tumorigenesis and metastasis makes it a promising target for studying mechanisms of cancer development and identifying novel therapeutic strategies. The SPOP-L Antibody is a valuable tool for researchers seeking to investigate the impact of SPOP-L on cell signaling, protein turnover, and tumor growth, with the goal of advancing the understanding and treatment of cancer.
Antibody Name:
SPOPL Antibody (PACO57988)
Antibody SKU:
PACO57988
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Speckle-type POZ protein-like protein (1-120AA)
Western Blot. Positive WB detected in: A549 whole cell lysate. All lanes: SPOPL antibody at 6.3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa.
Background:
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.
SPOPL: In complex with a cullin, may act in ubiquitination and proteasomal degradation processes. Belongs to the Tdpoz family.Protein type: Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 2q22.1Molecular Function: protein bindingBiological Process: negative regulation of protein ubiquitination; proteasomal ubiquitin-dependent protein catabolic process
