The SPOP Polyclonal Antibody (CAB7621) is a valuable tool for researchers studying the speckle-type POZ protein (SPOP), a key player in the regulation of protein degradation and the ubiquitin-proteasome system. This antibody, produced in rabbits, has high affinity for human samples and has been validated for use in Western blot applications. It specifically binds to the SPOP protein, allowing for precise detection and analysis in various cell types.SPOP is known to be involved in the degradation of several important cellular proteins, including those that regulate cell growth, apoptosis, and DNA repair. It has been implicated in cancer development and progression, making it a promising target for cancer research.
By studying the function of SPOP, researchers can gain valuable insights into the mechanisms underlying tumorigenesis and potentially identify new therapeutic strategies for treating cancer.The SPOP Polyclonal Antibody is a reliable tool for investigating the role of SPOP in cancer and other cellular processes. Its high specificity and sensitivity make it ideal for use in immunology, oncology, and cell biology research projects. By understanding the function of SPOP at the molecular level, researchers can contribute to the development of innovative treatments for a variety of diseases.
Product Name:
SPOP Rabbit Polyclonal Antibody
SKU:
CAB7621
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of mouse SPOP (NP_079563.2).
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Located in nuclear speck. Is expressed in lung; metanephros; and pancreas. Orthologous to human SPOP (speckle type BTB/POZ protein).
Purification Method:
Affinity purification
Gene ID:
20747
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SPOP antibody (CAB7621) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
