The SPIRE1 Antibody (PAC012437) is a vital tool for researchers investigating the function of SPIRE1, a protein involved in actin filament nucleation and transport processes within the cell. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting SPIRE1 in various experimental settings, including Western blot applications. By targeting the SPIRE1 protein, this antibody enables detailed analysis and visualization of SPIRE1 expression and function in different cell types, making it an essential reagent for studies in cell biology and cytoskeletal dynamics.
SPIRE1 is known to play a crucial role in regulating actin dynamics, which are essential for cell shape, movement, and intracellular transport processes. Dysregulation of SPIRE1 has been implicated in various pathological conditions, including neurological disorders and cancer, highlighting the significance of studying its function. By utilizing the SPIRE1 Antibody, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and potentially identify novel therapeutic targets for intervention.
SPIRE1: Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in vesicle transport processes providing a novel link between actin organization and intracellular transport. Belongs to the spire family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 18p11.21Cellular Component: cell cortex; cleavage furrow; cytoplasmic vesicle membraneBiological Process: actin cytoskeleton organization and biogenesis; establishment of meiotic spindle localization; intracellular transport; polar body extrusion after meiotic divisions; vesicle-mediated transport
UniProt Protein Details:
NCBI Summary:
Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008]
