The SPINT2 Polyclonal Antibody (CAB6749) is a valuable tool for research involving SPINT2, a protein known for its role in regulating protease activity and cell signaling pathways. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the SPINT2 protein, allowing for precise detection and analysis in various cell types.SPINT2, also known as hepatocyte growth factor activator inhibitor 2 (HAI-2), has been implicated in cancer progression, tissue remodeling, and inflammation. Its ability to modulate protease activity makes it a promising target for research on cancer metastasis and tumor microenvironment dynamics.
By studying the function of SPINT2, researchers can gain insights into the underlying mechanisms of disease progression and potentially identify new therapeutic strategies for cancer treatment.Overall, the SPINT2 Polyclonal Antibody is a valuable tool for researchers interested in exploring the role of SPINT2 in cancer biology, tissue homeostasis, and inflammation. Its high specificity and sensitivity make it an ideal choice for studies aiming to unravel the complex signaling networks involving SPINT2 in various biological processes.
Product Name:
SPINT2 Rabbit Polyclonal Antibody
SKU:
CAB6749
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 28-197 of human SPINT2 (NP_066925.1).
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10653
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of MCF-7 cells, using SPINT2 Antibody (CAB6749) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
