The SPINK9 Polyclonal Antibody (PACO60072) is a valuable tool for researchers studying SPINK9, a protein with potential implications in skin biology and disease. This antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it suitable for a variety of experimental applications. It has been validated for use in Western blotting and other immunological techniques, enabling the detection and analysis of SPINK9 expression in different cell types.SPINK9 is a serine protease inhibitor that has been linked to processes such as skin barrier function and wound healing. Its role in regulating protease activity and maintaining skin homeostasis suggests its involvement in skin diseases and conditions.
Investigating the function and expression of SPINK9 can provide insights into dermatological disorders, skin aging, and potential therapeutic targets for skin-related ailments.Overall, the SPINK9 Polyclonal Antibody offers a reliable tool for researchers interested in exploring the molecular mechanisms of SPINK9 and its relevance to skin health and disease. Its applications in various research areas, including dermatology and molecular biology, make it a valuable asset in advancing our understanding of SPINK9 biology and its potential clinical implications.
Antibody Name:
SPINK9 Antibody (PACO60072)
Antibody SKU:
PACO60072
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Serine protease inhibitor Kazal-type 9 protein (20-86AA)
IHC image of PACO60072 diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.
The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015]
