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SPINK6 Antibody (PACO57220)

SKU:
PACO57220
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SPINK6 Antibody PACO57220
  • SPINK6 Antibody PACO57220
€339

Description

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SPINK6 Antibody (PACO57220)

The SPINK6 Antibody (PAC057220) is a key tool for researchers studying SPINK6, a serine protease inhibitor involved in skin barrier function and inflammatory responses. This polyclonal antibody, raised in rabbits, is highly specific for human samples and has been validated for use in various applications, particularly in immunohistochemistry studies.SPINK6 is known for its role in regulating protease activity in the skin, helping to maintain the integrity of the skin barrier and prevent excessive inflammation.

Dysregulation of SPINK6 has been linked to various skin conditions, making it a target of interest in dermatology research. By using the SPINK6 Antibody, researchers can effectively detect and study SPINK6 expression in skin tissues, contributing to a deeper understanding of its function and potential therapeutic applications in skin disorders.

Antibody Name:SPINK6 Antibody (PACO57220)
Antibody SKU:PACO57220
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:Human
Immunogen:Recombinant Human Serine protease inhibitor Kazal-type 6 protein (24-80AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO57220 diluted at 1:400 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Product ImageIHC image of PACO57220 diluted at 1:400 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.
Synonyms:Serine protease inhibitor Kazal-type 6 (Kallikrein inhibitor), SPINK6
UniProt Protein Function:SPINK6: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 5q32Cellular Component: extracellular regionMolecular Function: serine-type endopeptidase inhibitor activity
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
UniProt Code:Q6UWN8
NCBI GenInfo Identifier:305632839
NCBI Gene ID:404203
NCBI Accession:NP_001182219.1
UniProt Secondary Accession:Q6UWN8,Q8N5P0, E0X656
UniProt Related Accession:Q6UWN8
Molecular Weight:8,585 Da
NCBI Full Name:serine protease inhibitor Kazal-type 6
NCBI Synonym Full Names:serine peptidase inhibitor, Kazal type 6
NCBI Official Symbol:SPINK6  
NCBI Official Synonym Symbols:BUSI2; UNQ844  
NCBI Protein Information:serine protease inhibitor Kazal-type 6; acrosin inhibitor; kallikrein inhibitor; protease inhibitor H
UniProt Protein Name:Serine protease inhibitor Kazal-type 6
UniProt Synonym Protein Names:Kallikrein inhibitor
Protein Family:Serine protease inhibitor
UniProt Gene Name:SPINK6  
UniProt Entry Name:ISK6_HUMAN
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