The SPINK6 Antibody (PAC022592) is a highly specific and sensitive tool for research involving SPINK6, a serine protease inhibitor. This antibody, produced in rabbits, has been validated for use in various applications, including Western blotting and immunohistochemistry. It binds specifically to the SPINK6 protein, allowing for accurate detection and analysis in different cell types.SPINK6 is known for its role in skin barrier function, as well as its potential involvement in inflammatory skin conditions and cancer. Research on SPINK6 has shown its importance in skin homeostasis and its potential as a therapeutic target for skin disorders.
By studying the function and expression of SPINK6, researchers can gain valuable insights into the molecular mechanisms underlying skin health and diseases.Overall, the SPINK6 Antibody is a valuable tool for investigating the role of SPINK6 in skin biology and pathology, offering new possibilities for advancing our understanding of skin disorders and identifying potential therapeutic targets. Its high specificity and sensitivity make it a reliable choice for researchers working in the fields of dermatology, oncology, and immunology.
Antibody Name:
SPINK6 Antibody (PACO22592)
Antibody SKU:
PACO22592
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human SPINK6.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SPINK6 antibody.
Background:
Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.
Synonyms:
Serine protease inhibitor Kazal-type 6; SPINK6;
UniProt Protein Function:
SPINK6: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 5q32Cellular Component: extracellular regionMolecular Function: serine-type endopeptidase inhibitor activity
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
