The SPIC Antibody (PAC021897) is a polyclonal antibody specifically designed for research involving the SPIC protein. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in various applications, including Western blot. The SPIC Antibody binds to the SPIC protein, allowing for accurate detection and analysis in a wide range of cell types.SPIC is a transcription factor that plays a crucial role in immune regulation, specifically in the development and function of T cells. Its involvement in immune responses makes it a key target for research in immunology and cancer studies.
Understanding the function of SPIC can provide valuable insights into diseases such as cancer, autoimmune disorders, and inflammatory conditions, potentially leading to the development of new therapies and treatments.Overall, the SPIC Antibody is a valuable tool for researchers looking to investigate the role of SPIC in immune regulation and its implications in various disease states. Its high reactivity and specificity make it an essential component in studies aimed at advancing our understanding of immune function and disease pathology.
Antibody Name:
SPIC Antibody (PACO21897)
Antibody SKU:
PACO21897
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human SPIC.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells and HeLa cells, using SPIC antibody.
Synonyms:
Transcription factor Spi-C; SPIC;
UniProt Protein Function:
SPIC: Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression. Belongs to the ETS family.
UniProt Protein Details:
Protein type:DNA-binding
Chromosomal Location of Human Ortholog: 12q23.2
Cellular Component: nucleus
Biological Process: cell differentiation; regulation of transcription from RNA polymerase II promoter
NCBI Summary:
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
