SPIC Antibody (PACO01529)
- SKU:
- PACO01529
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SPIC Antibody (PACO01529)
The SPIC Polyclonal Antibody (PACO01529) is a valuable tool for researchers studying SPIC, a transcription factor involved in immune regulation and inflammation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SPIC protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.SPIC plays a crucial role in the immune response by regulating the expression of genes involved in inflammation and immune cell activation.
Its involvement in immune system signaling pathways makes it a key target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of SPIC can provide valuable insights for developing new therapeutic strategies that modulate immune responses in these disease contexts.
| Antibody Name: | SPIC Antibody |
| Antibody SKU: | PACO01529 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human Spi-C. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SPIC; Transcription factor Spi-C |
| UniProt Protein Function: | SPIC: Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression. Belongs to the ETS family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 12q23.2 Cellular Component: nucleus Biological Process: cell differentiation; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016] |
| UniProt Code: | Q8N5J4 |
| NCBI GenInfo Identifier: | 22748707 |
| NCBI Gene ID: | 121599 |
| NCBI Accession: | NP_689536.1 |
| UniProt Related Accession: | Q8N5J4 |
| Molecular Weight: | 29kd |
| NCBI Full Name: | transcription factor Spi-C |
| NCBI Synonym Full Names: | Spi-C transcription factor |
| NCBI Official Symbol: | SPICÂ Â |
| NCBI Official Synonym Symbols: | SPI-CÂ Â |
| NCBI Protein Information: | transcription factor Spi-C |
| UniProt Protein Name: | Transcription factor Spi-C |
| Protein Family: | SpiC |
| UniProt Gene Name: | SPICÂ Â |
| UniProt Entry Name: | SPIC_HUMAN |
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