SPHK1 Rabbit Polyclonal Antibody (CAB0139)
- SKU:
- CAB0139
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | SPHK1 Rabbit Polyclonal Antibody |
SKU: | CAB0139 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-384 of human SPHK1 (NP_001136074.1). |
Sequence: | TLML TERR NHAR ELVR SEEL GRWD ALVV MSGD GLMH EVVN GLME RPDW ETAI QKPL CSLP AGSG NALA ASLN HYAG YEQV TNED LLTN CTLL LCRR LLSP MNLL SLHT ASGL RLFS VLSL AWGF IADV DLES EKYR RLGE MRFT LGTF LRLA ALRT YRGR LAYL PVGR VGSK TPAS PVVV QQGP VDAH LVPL EEPV PSHW TVVP DEDF VLVL ALLH SHLG SEMF AAPM GRCA AGVM HLFY VRAG VSRA MLLR LFLA MEKG RHME YECP YLVY VPVV AFRL EPKD GKGV FAVD GELM VSEA VQGQ VHPN YFWM VSGC VEPP PSWK PQQM PPPE EPL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SPHK; SPHK1 |
Positive Sample: | SW480,HeLa,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Nucleus. |
Calculated MW: | 43kDa |
Observed MW: | 55kDa |
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 8877 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |