SPG20 Rabbit Polyclonal Antibody (CAB17653)
- SKU:
- CAB17653
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | SPG20 Rabbit Polyclonal Antibody |
SKU: | CAB17653 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human SPG20 (NP_055902.1). |
Sequence: | MEQE PQNG EPAE IKII REAY KKAF LFVN KGLN TDEL GQKE EAKN YYKQ GIGH LLRG ISIS SKES EHTG PGWE SARQ MQQK MKET LQNV RTRL EILE KGLA TSLQ NDLQ EVPK LYPE FPPK DMCE KLPE PQSF SSAP QHAE VNGN TSTP SAGA VAAP ASLS LPSQ SCPA EAPP AYTP QAAE GHYT VSYG TDSG EFSS VGEE FYRN HSQP PPLE TLGL DADE LILI PNGV QIFF VNPA GEVS APSY PGYL RIVR FLDN SLDT VLNR PPGF LQVC DWLY PLVP DRSP VLKC TAGA YMFP DTML QAAG CFVG VVLS SELP EDDR ELFE DLLR QMSD LRLQ ANWN RAEE ENEF QI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SPG20; TAHCCP1 |
Positive Sample: | K-562,HeLa,293T,Mouse liver,Mouse heart,Mouse brain,Rat spleen,Rat lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, lipid droplet, mitochondrial outer membrane, plasma membrane |
Calculated MW: | 73kDa |
Observed MW: | 73kDa |
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
Purification Method: | Affinity purification |
Gene ID: | 23111 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |