The Spermine Synthase Polyclonal Antibody (CAB9154) is a valuable tool for researchers studying spermine synthase, an enzyme involved in polyamine metabolism. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the spermine synthase protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in biochemistry, molecular biology, and cancer research.Spermine synthase plays a crucial role in the biosynthesis of spermine, a polyamine that is essential for cell growth, proliferation, and differentiation.
Dysregulation of spermine synthase has been implicated in various disease states, including cancer, neurodegenerative disorders, and metabolic diseases. By understanding the functions and regulation of spermine synthase, researchers can gain insight into the underlying mechanisms of these diseases and potentially identify novel therapeutic targets for intervention.
Product Name:
SMS Rabbit Polyclonal Antibody
SKU:
CAB9154
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human SMS (NP_004586.2).
This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6611
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SMS Rabbit pAb (CAB9154) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
