The SPEB Antibody (PACO52142) is a highly specific and reliable tool for researchers studying the SPEB protein. SPEB is a key player in processes related to DNA repair and replication, making it an important target for investigations into cancer, aging, and genetic disorders.Produced in rabbits, this polyclonal antibody is optimized for use in Western blot applications and is highly reactive with human samples. Its ability to bind specifically to the SPEB protein allows for precise detection and analysis in a variety of cell types.
This makes it an invaluable tool for studies in molecular biology, genetics, and oncology.With its potential implications in various diseases and biological processes, the SPEB Antibody is a valuable resource for researchers looking to deepen their understanding of the role of SPEB in cellular function and disease pathology. By enabling accurate and sensitive detection of SPEB, this antibody can help advance research in fields such as cancer biology, genetic disorders, and aging-related studies.
Antibody Name:
speB Antibody (PACO52142)
Antibody SKU:
PACO52142
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Streptococcus pyogenes
Immunogen:
Recombinant Streptococcus pyogenes Streptopain protein (146-398AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: speB antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 44 kDa. Observed band size: 44 kDa.
Background:
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.
Synonyms:
Streptopain (EC 3.4.22.10) (Exotoxin type B) (SPE B) (Streptococcal cysteine proteinase) (Streptococcus peptidase A) (SPP), speB
UniProt Protein Function:
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.
