SPDL1 Antibody (PACO20599)
- SKU:
- PACO20599
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SPDL1 Antibody (PACO20599)
The SPDL1 Polyclonal Antibody (PAC020599) is a research tool specifically designed for the study of SPDL1, a protein involved in spindle pole body duplication and centrosome maturation. This antibody, derived from rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By targeting the SPDL1 protein, this antibody enables researchers to detect and analyze SPDL1 expression in various cell types, making it an essential tool for studies in cell biology and cancer research.SPDL1 plays a crucial role in regulating the duplication of spindle pole bodies and the maturation of centrosomes, processes that are essential for proper cell division and maintenance of genomic stability.
Dysregulation of SPDL1 has been implicated in various diseases, including cancer, where abnormal cell division can lead to tumor formation and progression. By studying the function of SPDL1, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
| Antibody Name: | SPDL1 Antibody (PACO20599) |
| Antibody SKU: | PACO20599 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human SPDL1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20599(SPDL1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20599(SPDL1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. |
| Synonyms: | spindle apparatus coiled-coil protein 1 |
| UniProt Protein Function: | CCDC99: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Belongs to the Spindly family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 5q35.1Cellular Component: cytosol; nucleus; outer kinetochore of condensed chromosome; spindle poleMolecular Function: enzyme binding; kinetochore binding; protein bindingBiological Process: establishment of mitotic spindle orientation; mitotic metaphase plate congression; sister chromatid cohesion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q96EA4 |
| NCBI GenInfo Identifier: | 296452913 |
| NCBI Gene ID: | 54908 |
| NCBI Accession: | Q96EA4.2 |
| UniProt Secondary Accession: | Q96EA4,Q8TEC8, Q9HD44, Q9NX97, B4E393, C9JS47 |
| UniProt Related Accession: | Q96EA4 |
| Molecular Weight: | 61,015 Da |
| NCBI Full Name: | Protein Spindly |
| NCBI Synonym Full Names: | spindle apparatus coiled-coil protein 1 |
| NCBI Official Symbol: | SPDL1Â Â |
| NCBI Official Synonym Symbols: | CCDC99Â Â |
| NCBI Protein Information: | protein Spindly |
| UniProt Protein Name: | Protein Spindly |
| UniProt Synonym Protein Names: | Arsenite-related gene 1 protein; Coiled-coil domain-containing protein 99 |
| Protein Family: | Protein Spindly |
| UniProt Gene Name: | SPDL1Â Â |
| UniProt Entry Name: | SPDLY_HUMAN |
| Antibodies |
| SPDL1 Antibody (PACO02989) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
SPDL1 Antibody (PACO38966)
$407
SPDL1 Antibody (PACO20598)
$407
SPDL1 Antibody (PACO15038)
$407
SPDL1 Antibody (PACO15039)
$407
SPDL1 Antibody (PACO02989)
$323
ompF Antibody (PACO64865)
$407
ANKEF1 Antibody (PACO64597)
$407
CYP2A13 Antibody (PACO64657)
$383
RIMS4 Antibody (PACO64925)
$383