SPDL1 Antibody (PACO15039)
- SKU:
- PACO15039
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
SPDL1 Antibody (PACO15039)
The SPDL1 Polyclonal Antibody (PAC015039) is a valuable tool for researchers studying SPDL1, a protein involved in spindle dynamics and cell division. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SPDL1 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in cell biology and cancer research.SPDL1, also known as SPINDLY, is essential for proper chromosome segregation during cell division and is implicated in maintaining genomic stability.
Dysregulation of SPDL1 has been linked to chromosomal instability and tumorigenesis, highlighting its potential as a target for cancer therapy and research. By understanding the functions and interactions of SPDL1, researchers can gain insights into cell division mechanisms and potential therapeutic strategies for cancer treatment.
| Antibody Name: | SPDL1 Antibody (PACO15039) |
| Antibody SKU: | PACO15039 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human SPDL1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO15039(SPDL1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
| Background: | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect. |
| Synonyms: | Spindle apparatus coiled-coil protein 1 |
| UniProt Protein Function: | CCDC99: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Belongs to the Spindly family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 5q35.1Cellular Component: cytosol; nucleus; outer kinetochore of condensed chromosome; spindle poleMolecular Function: enzyme binding; kinetochore binding; protein bindingBiological Process: establishment of mitotic spindle orientation; mitotic metaphase plate congression; sister chromatid cohesion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q96EA4 |
| NCBI GenInfo Identifier: | 296452913 |
| NCBI Gene ID: | 54908 |
| NCBI Accession: | Q96EA4.2 |
| UniProt Secondary Accession: | Q96EA4,Q8TEC8, Q9HD44, Q9NX97, B4E393, C9JS47 |
| UniProt Related Accession: | Q96EA4 |
| Molecular Weight: | 61,015 Da |
| NCBI Full Name: | Protein Spindly |
| NCBI Synonym Full Names: | spindle apparatus coiled-coil protein 1 |
| NCBI Official Symbol: | SPDL1Â Â |
| NCBI Official Synonym Symbols: | CCDC99Â Â |
| NCBI Protein Information: | protein Spindly |
| UniProt Protein Name: | Protein Spindly |
| UniProt Synonym Protein Names: | Arsenite-related gene 1 protein; Coiled-coil domain-containing protein 99 |
| Protein Family: | Protein Spindly |
| UniProt Gene Name: | SPDL1Â Â |
| UniProt Entry Name: | SPDLY_HUMAN |
| Antibodies |
| SPDL1 Antibody (PACO02989) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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