SPCS1 Antibody (PACO42642)
- SKU:
- PACO42642
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SPCS1 Antibody (PACO42642)
The SPCS1 Polyclonal Antibody (PAC04242) is designed for research involving SPCS1, a protein involved in proteasome-mediated degradation and endoplasmic reticulum (ER) stress response. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot applications. It binds specifically to the SPCS1 protein, allowing for its detection and analysis in various cell types, making it ideal for studies in proteostasis and ER stress biology.SPCS1 is a critical component of the SPCS complex, which plays a crucial role in regulating ER-associated protein degradation (ERAD) and maintaining protein homeostasis in the ER.
Dysregulation of SPCS1 has been implicated in various diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular physiology and disease pathology. Understanding the function of SPCS1 can provide insights into potential therapeutic targets for these conditions.Overall, the SPCS1 Polyclonal Antibody is a valuable tool for researchers investigating the role of SPCS1 in proteostasis, ER stress, and disease pathogenesis. Its high specificity and reactivity make it a reliable choice for studies aiming to elucidate the mechanisms underlying protein turnover and ER quality control processes.
| Antibody Name: | SPCS1 Antibody (PACO42642) |
| Antibody SKU: | PACO42642 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Signal peptidase complex subunit 1 protein (70-102AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of MCF-7 cells using PACO42642 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. |
| Synonyms: | Signal peptidase complex subunit 1 (EC 3.4.-.-) (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit), SPCS1, SPC12 |
| UniProt Protein Function: | SPCS1: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the SPCS1 family. |
| UniProt Protein Details: | Protein type:Protease; Endoplasmic reticulum; Amino Acid Metabolism - lysine degradation; Cofactor and Vitamin Metabolism - biotin; Membrane protein, multi-pass; EC 3.4.-.-; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; signal peptidase complex Molecular Function:peptidase activity; protein binding Biological Process: protein targeting to ER; SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; signal peptide processing; translation; gene expression; proteolysis; regulation of insulin secretion |
| UniProt Code: | Q9Y6A9 |
| NCBI GenInfo Identifier: | 557952606 |
| NCBI Gene ID: | 28972 |
| NCBI Accession: | Q9Y6A9.4 |
| UniProt Secondary Accession: | Q9Y6A9,Q9BVW1, B3KNF8, |
| UniProt Related Accession: | Q9Y6A9 |
| Molecular Weight: | 169 |
| NCBI Full Name: | Signal peptidase complex subunit 1 |
| NCBI Synonym Full Names: | signal peptidase complex subunit 1 homolog (S. cerevisiae) |
| NCBI Official Symbol: | SPCS1Â Â |
| NCBI Official Synonym Symbols: | SPC1; SPC12; HSPC033; YJR010C-AÂ Â |
| NCBI Protein Information: | signal peptidase complex subunit 1; SPase 12 kDa subunit; signal peptidase 12kDa; microsomal signal peptidase 12 kDa subunit |
| UniProt Protein Name: | Signal peptidase complex subunit 1 |
| UniProt Synonym Protein Names: | Microsomal signal peptidase 12 kDa subunit; SPase 12 kDa subunit |
| Protein Family: | Signal peptidase complex |
| UniProt Gene Name: | SPCS1Â Â |
| UniProt Entry Name: | SPCS1_HUMAN |
| Antibodies |
| SPCS1 Antibody (PACO12427) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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