The SPATA16 Polyclonal Antibody (PACO47066) is a valuable tool for researchers studying SPATA16, a protein involved in spermatogenesis and male fertility. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SPATA16 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in reproductive biology and infertility research.
SPATA16, also known as spermatogenesis-associated protein 16, plays a critical role in the development and maturation of sperm cells. Understanding the functions of SPATA16 is crucial for advancing knowledge in male reproductive health and fertility issues. Research on SPATA16 could have implications for the diagnosis and treatment of male infertility and other reproductive disorders, making this antibody a valuable resource for scientists working in this field.
Antibody Name:
SPATA16 Antibody (PACO47066)
Antibody SKU:
PACO47066
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Spermatogenesis-associated protein 16 protein (238-475AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO47066 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human lung cancer using PACO47066 at dilution of 1:100.
Background:
Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.
Synonyms:
Spermatogenesis-associated protein 16 (Testis development protein NYD-SP12), SPATA16
UniProt Protein Function:
SPATA16: Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. Defects in SPATA16 are the cause of spermatogenic failure type 6 (SPGF6); also known as round-headed spermatozoa. An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. An autosomal recessive variation of SPATA16 has been shown to be responsible for the disease in a consanguineous family with members homozygous for the variation. Belongs to the SPATA16 family.Chromosomal Location of Human Ortholog: 3q26.31Disease: Spermatogenic Failure 6
UniProt Protein Details:
NCBI Summary:
This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis. [provided by RefSeq, May 2010]
