The SPATA16 Polyclonal Antibody (PAC015163) is a valuable tool for researchers studying SPATA16, a protein involved in spermatogenesis and fertility. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as Western blotting. By binding specifically to the SPATA16 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in reproductive biology and infertility research.SPATA16 plays a crucial role in sperm development and function, making it a key player in male fertility. Dysregulation of SPATA16 has been linked to various reproductive disorders, making it a significant target for studies on male infertility and assisted reproductive technologies.
Understanding the function of SPATA16 is essential for developing new treatments and interventions to improve male reproductive health.Overall, the SPATA16 Polyclonal Antibody is a reliable tool for researchers interested in studying SPATA16 and its role in male fertility and reproductive health. Its high reactivity and specificity make it a valuable asset for advancing our understanding of spermatogenesis and developing innovative therapies in the field of reproductive biology.
Antibody Name:
SPATA16 Antibody (PACO15163)
Antibody SKU:
PACO15163
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human SPATA16
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15163(SPATA16 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15163(SPATA16 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis.
Synonyms:
spermatogenesis associated 16
UniProt Protein Function:
SPATA16: Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. Defects in SPATA16 are the cause of spermatogenic failure type 6 (SPGF6); also known as round-headed spermatozoa. An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. An autosomal recessive variation of SPATA16 has been shown to be responsible for the disease in a consanguineous family with members homozygous for the variation. Belongs to the SPATA16 family.Chromosomal Location of Human Ortholog: 3q26.31Disease: Spermatogenic Failure 6
UniProt Protein Details:
NCBI Summary:
This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis. [provided by RefSeq, May 2010]
