SPATA16 Antibody (PACO15162)
- SKU:
- PACO15162
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SPATA16 Antibody (PACO15162)
The SPATA16 Polyclonal Antibody (PAC015162) is a valuable tool for research involving SPATA16, a protein involved in spermatogenesis and fertility. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in Western blot applications. By binding to the SPATA16 protein, this antibody allows for accurate detection and analysis in various cell types, facilitating studies in reproductive biology and infertility research.SPATA16, also known as Spermatogenesis-Associated 16, plays a crucial role in the process of sperm production and male fertility.
Understanding the function of SPATA16 is essential for advancing knowledge in reproductive health and developing interventions for infertility treatment. Research on SPATA16 may lead to insights into male infertility mechanisms and potential therapeutic targets for improving reproductive outcomes.Overall, the SPATA16 Polyclonal Antibody is a valuable tool for researchers studying spermatogenesis, fertility, and reproductive health. Its specificity and sensitivity make it an ideal choice for investigations into the role of SPATA16 in infertility and male reproductive disorders.
| Antibody Name: | SPATA16 Antibody (PACO15162) |
| Antibody SKU: | PACO15162 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human SPATA16 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15162(SPATA16 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: Human liver cancer tissue, Primary antibody: PACO15162(SPATA16 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15162(SPATA16 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis. The SPATA16 protein contains a region of homology to the mouse male enhanced antigen-2, a SCOP domain belonging to the tetratricopeptide repeat-like superfamily, 3 glycosylation sites, and several phosphorylation sites. The mouse and human proteins share 77% sequence identity. Northern blot analysis of multiple human tissues detected a strong signal in testis and weak expression in pancreas and kidney. Laser confocal microscopy localized a GFP-SPATA16 fusion protein specifically to the Golgi apparatus. |
| Synonyms: | Spermatogenesis associated 16 |
| UniProt Protein Function: | SPATA16: Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. Defects in SPATA16 are the cause of spermatogenic failure type 6 (SPGF6); also known as round-headed spermatozoa. An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. An autosomal recessive variation of SPATA16 has been shown to be responsible for the disease in a consanguineous family with members homozygous for the variation. Belongs to the SPATA16 family.Chromosomal Location of Human Ortholog: 3q26.31Disease: Spermatogenic Failure 6 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9BXB7 |
| NCBI GenInfo Identifier: | 190194384 |
| NCBI Gene ID: | 83893 |
| NCBI Accession: | NP_114161.3 |
| UniProt Secondary Accession: | Q9BXB7,Q0R0N4, Q0R0S0, Q0R0W2, Q0R129, Q0R131, Q0R140 Q0R1B8, Q0R1G5, Q0R1I2 |
| UniProt Related Accession: | Q9BXB7 |
| Molecular Weight: | 65,263 Da |
| NCBI Full Name: | spermatogenesis-associated protein 16 |
| NCBI Synonym Full Names: | spermatogenesis associated 16 |
| NCBI Official Symbol: | SPATA16 |
| NCBI Official Synonym Symbols: | SPGF6; NYD-SP12 |
| NCBI Protein Information: | spermatogenesis-associated protein 16 |
| UniProt Protein Name: | Spermatogenesis-associated protein 16 |
| UniProt Synonym Protein Names: | Testis development protein NYD-SP12 |
| Protein Family: | Spermatogenesis-associated protein |
| UniProt Gene Name: | SPATA16 |
| UniProt Entry Name: | SPT16_HUMAN |
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