UniProt Protein Function: | SPANXD: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. [provided by RefSeq, Jul 2008]Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq27.1Cellular Component: cytoplasm; nucleus |
UniProt Protein Details: | |
NCBI Summary: | Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014] |
UniProt Code: | Q9BXN6 |
NCBI GenInfo Identifier: | 14192939 |
NCBI Gene ID: | 64648 |
NCBI Accession: | NP_115793.1 |
UniProt Secondary Accession: | Q9BXN6,Q5JWI1 |
UniProt Related Accession: | Q9BXN6 |
Molecular Weight: | 11,029 Da |
NCBI Full Name: | sperm protein associated with the nucleus on the X chromosome D |
NCBI Synonym Full Names: | SPANX family, member D |
NCBI Official Symbol: | SPANXDÂ Â |
NCBI Official Synonym Symbols: | CT11.4; SPANXE; SPANX-C; SPANX-D; SPANX-E; dJ171K16.1Â Â |
NCBI Protein Information: | sperm protein associated with the nucleus on the X chromosome D; SPANX family, member E; cancer/testis antigen 11.4; nuclear-associated protein SPAN-Xd; nuclear-associated protein SPAN-Xe; cancer/testis antigen family 11, member 4; sperm protein associated with the nucleus, X chromosome, family member D; sperm protein associated with the nucleus, X chromosome, family member E |
UniProt Protein Name: | Sperm protein associated with the nucleus on the X chromosome D |
UniProt Synonym Protein Names: | Cancer/testis antigen 11.4; CT11.4; Nuclear-associated protein SPAN-Xd; SPANX-D; SPANX family member D |
Protein Family: | Sperm protein associated with the nucleus on the X chromosome |
UniProt Gene Name: | SPANXDÂ Â |
UniProt Entry Name: | SPNXD_HUMAN |