The SPANXC Monoclonal Antibody (PAC041478) is a valuable tool for researchers studying SPANXC, a cancer/testis antigen implicated in tumorigenesis and cancer progression. This antibody, generated in mouse, has high specificity for human samples and is suitable for various applications including immunohistochemistry and flow cytometry. By targeting the SPANXC protein, researchers can investigate its role in cancer development and potentially identify new therapeutic targets in oncology research.
SPANXC, a member of the SPANX family, is typically expressed in germline cells but can also be found in a variety of cancer types. Its involvement in cell proliferation, invasion, and immune evasion makes it a promising candidate for further study in cancer biology. Understanding the function of SPANXC may lead to new insights into tumor mechanisms and aid in the development of targeted therapies for cancer treatment.
Antibody Name:
SPANXC Antibody (PACO41478)
Antibody SKU:
PACO41478
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Sperm protein associated with the nucleus on the X chromosome C protein (1-97AA)
Immunohistochemistry of paraffin-embedded human skin tissue using PACO41478 at dilution of 1:100.
Background:
nucleus
Synonyms:
Sperm protein associated with the nucleus on the X chromosome C (Cancer/testis antigen 11.3) (CT11.3) (Cancer/testis-associated protein CTp11) (Nuclear-associated protein SPAN-Xc) (SPANX-C) (SPANX family member C), SPANXC
UniProt Protein Function:
SPANXC: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq27.1Cellular Component: cytoplasm; nucleus
